The functions of animal microRNAs
V Ambros - Nature, 2004 - nature.com
V Ambros
Nature, 2004•nature.comMicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary
messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and
many of these are phylogenetically conserved. With miRNA roles identified in
developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the
nervous system, evidence is mounting that animal miRNAs are more numerous, and their
regulatory impact more pervasive, than was previously suspected.
messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and
many of these are phylogenetically conserved. With miRNA roles identified in
developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the
nervous system, evidence is mounting that animal miRNAs are more numerous, and their
regulatory impact more pervasive, than was previously suspected.
Abstract
MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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