Extracellular NAD+ induces a rise in [Ca2+] i in activated human monocytes via engagement of P2Y1 and P2Y11 receptors
C Klein, A Grahnert, A Abdelrahman, CE Müller… - Cell calcium, 2009 - Elsevier
Extracellular nicotinamide adenine dinucleotide (NAD+) is known to increase the
intracellular calcium concentration [Ca2+] i in different cell types and by various
mechanisms. Here we show that NAD+ triggers a transient rise in [Ca2+] i in human
monocytes activated with lipopolysaccharide (LPS), which is caused by a release of Ca2+
from IP3-responsive intracellular stores and an influx of extracellular Ca2+. By the use of P2
receptor-selective agonists and antagonists we demonstrate that P2 receptors play a role in …
intracellular calcium concentration [Ca2+] i in different cell types and by various
mechanisms. Here we show that NAD+ triggers a transient rise in [Ca2+] i in human
monocytes activated with lipopolysaccharide (LPS), which is caused by a release of Ca2+
from IP3-responsive intracellular stores and an influx of extracellular Ca2+. By the use of P2
receptor-selective agonists and antagonists we demonstrate that P2 receptors play a role in …