[PDF][PDF] Dysregulation of the cytokine GM-CSF induces spontaneous phagocyte invasion and immunopathology in the central nervous system
Immunity, 2017•cell.com
Chronic inflammatory diseases are influenced by dysregulation of cytokines. Among them,
granulocyte macrophage colony stimulating factor (GM-CSF) is crucial for the pathogenic
function of T cells in preclinical models of autoimmunity. To study the impact of dysregulated
GM-CSF expression in vivo, we generated a transgenic mouse line allowing the induction of
GM-CSF expression in mature, peripheral helper T (Th) cells. Antigen-independent GM-CSF
release led to the invasion of inflammatory myeloid cells into the central nervous system …
granulocyte macrophage colony stimulating factor (GM-CSF) is crucial for the pathogenic
function of T cells in preclinical models of autoimmunity. To study the impact of dysregulated
GM-CSF expression in vivo, we generated a transgenic mouse line allowing the induction of
GM-CSF expression in mature, peripheral helper T (Th) cells. Antigen-independent GM-CSF
release led to the invasion of inflammatory myeloid cells into the central nervous system …
Summary
Chronic inflammatory diseases are influenced by dysregulation of cytokines. Among them, granulocyte macrophage colony stimulating factor (GM-CSF) is crucial for the pathogenic function of T cells in preclinical models of autoimmunity. To study the impact of dysregulated GM-CSF expression in vivo, we generated a transgenic mouse line allowing the induction of GM-CSF expression in mature, peripheral helper T (Th) cells. Antigen-independent GM-CSF release led to the invasion of inflammatory myeloid cells into the central nervous system (CNS), which was accompanied by the spontaneous development of severe neurological deficits. CNS-invading phagocytes produced reactive oxygen species and exhibited a distinct genetic signature compared to myeloid cells invading other organs. We propose that the CNS is particularly vulnerable to the attack of monocyte-derived phagocytes and that the effector functions of GM-CSF-expanded myeloid cells are in turn guided by the tissue microenvironment.
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