Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level
J Bauer, F Berkenbosch, AM Van Dam… - Journal of …, 1993 - Elsevier
Abstract Interleukin-1β (IL-1) is a cytokine which exerts many biological effects during
inflammation. In the present study, experimental allergic encephalomyelitis (EAE) was
induced in Lewis rats. During the various stages of EAE, the presence of IL-1 in the brain
was investigated using immunocytochemistry at both the light and ultrastructural level. Ten
days after immunization, IL-1 immunoreactivity was found in brains of animals which at this
time showed mild clinical signs. Outside the blood-brain barrier, IL-1 was localized in the …
inflammation. In the present study, experimental allergic encephalomyelitis (EAE) was
induced in Lewis rats. During the various stages of EAE, the presence of IL-1 in the brain
was investigated using immunocytochemistry at both the light and ultrastructural level. Ten
days after immunization, IL-1 immunoreactivity was found in brains of animals which at this
time showed mild clinical signs. Outside the blood-brain barrier, IL-1 was localized in the …