Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic …
Y Okuda, Y Nakatsuji, H Fujimura, H Esumi… - Journal of …, 1995 - Elsevier
A cytokine-mediated excessive increase in nitric oxide (NO) by macrophages or glial cells
via an inducible isoform of NO synthase (iNOS) has been proposed to play an important role
in demyelinating diseases. To further investigate the role of iNOS in demyelination,
experimental allergic encephalomyelitis (EAE), a known animal model of multiple sclerosis
(MS) in mice, was chosen in this study. A semiquantitative reverse transcriptase-polymerase
chain reaction (RT/PCR) analysis revealed an increase in the mRNA levels of iNOS and …
via an inducible isoform of NO synthase (iNOS) has been proposed to play an important role
in demyelinating diseases. To further investigate the role of iNOS in demyelination,
experimental allergic encephalomyelitis (EAE), a known animal model of multiple sclerosis
(MS) in mice, was chosen in this study. A semiquantitative reverse transcriptase-polymerase
chain reaction (RT/PCR) analysis revealed an increase in the mRNA levels of iNOS and …