Mechanisms of NO neurotoxicity
T Dalkara, M Endres, MA Moskowitz - Progress in brain research, 1998 - Elsevier
Publisher Summary This chapter describes the mechanisms of nitric oxide (NO)
neurotoxicity. NO is synthesized from L-arginine and molecular oxygen by NO synthases
(NOS). NOS has two constitutive––neuronal (Type 1) and endothelial (Type 3)––and one
inducible isoforms. The constitutive isoforms are calcium/calmodulin-dependent and
activated by transient elevations in intracellular calcium. High output NO synthesis by the
inducible isoform is cytotoxic and mediates the inflammatory actions of NO. These neurons …
neurotoxicity. NO is synthesized from L-arginine and molecular oxygen by NO synthases
(NOS). NOS has two constitutive––neuronal (Type 1) and endothelial (Type 3)––and one
inducible isoforms. The constitutive isoforms are calcium/calmodulin-dependent and
activated by transient elevations in intracellular calcium. High output NO synthesis by the
inducible isoform is cytotoxic and mediates the inflammatory actions of NO. These neurons …