[HTML][HTML] Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours

NP Seeram, SM Henning, Y Zhang, M Suchard, Z Li… - The Journal of …, 2006 - Elsevier
Ellagitannins (ETs) from pomegranate juice (PJ) are reported to have numerous biological
properties, but their absorption and metabolism in humans are poorly understood. To
investigate the pharmacokinetics of pomegranate ETs, 18 healthy volunteers were given
180 mL of PJ concentrate, and blood samples were obtained for 6 h afterwards. Twenty-four–
hour urine collections were obtained on the day before (− 1), the day of (0), and the day after
(+ 1) the study. Ellagic acid (EA) was detected in plasma of all subjects with a maximum …