Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity
L Moore, X Lu, N Ghebranious, S Tyner… - Mechanisms of ageing …, 2007 - Elsevier
Evidence has accumulated that p53, a prototypical tumor suppressor, may also influence
aspects of organismal aging. We have previously described a p53 mutant mouse model, the
p53+/m mouse, which is cancer resistant yet exhibits reduced longevity and premature
aging phenotypes. p53+/m mice express one full length p53 allele and one truncated p53
allele that is translated into a C-terminal fragment of p53 termed the M protein. The
augmented cancer resistance and premature aging phenotypes in the p53+/m mice are …
aspects of organismal aging. We have previously described a p53 mutant mouse model, the
p53+/m mouse, which is cancer resistant yet exhibits reduced longevity and premature
aging phenotypes. p53+/m mice express one full length p53 allele and one truncated p53
allele that is translated into a C-terminal fragment of p53 termed the M protein. The
augmented cancer resistance and premature aging phenotypes in the p53+/m mice are …