[HTML][HTML] Regulated Cleavage of Sterol Regulatory Element Binding Proteins Requires Sequences on Both Sides of the Endoplasmic Reticulum Membrane (∗)
Sterol regulatory element binding proteins (SREBP-1 and SREBP-2) are attached to the
endoplasmic reticulum (ER) and nuclear envelope by a hairpin domain consisting of two
transmembrane regions connected by a short lumenal loop of∼ 30 hydrophilic amino acids.
In sterol-depleted cells, a protease cleaves the protein in the region of the first
transmembrane domain, releasing an NH 2-terminal fragment of∼ 500 amino acids that
activates transcription of genes encoding the low density lipoprotein receptor and enzymes …
endoplasmic reticulum (ER) and nuclear envelope by a hairpin domain consisting of two
transmembrane regions connected by a short lumenal loop of∼ 30 hydrophilic amino acids.
In sterol-depleted cells, a protease cleaves the protein in the region of the first
transmembrane domain, releasing an NH 2-terminal fragment of∼ 500 amino acids that
activates transcription of genes encoding the low density lipoprotein receptor and enzymes …