[HTML][HTML] Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7α-hydroxylase

JH Miyake, XDT Doung, W Strauss, GL Moore… - Journal of Biological …, 2001 - ASBMB
The finding that expression of a cholesterol 7α-hydroxylase (CYP7A1) transgene in cultured
rat hepatoma cells caused a coordinate increase in lipogenesis and secretion of apoB-
containing lipoproteins led to the hypothesis that hepatic production of apoB-containing
lipoproteins may be linked to the expression of CYP7A1 (Wang, S.-L., Du, E., Martin, TD, and
Davis, RA (1997) J. Biol. Chem. 272, 19351–19358). To examine this hypothesis in vivo, a
transgene encoding CYP7A1 driven by the constitutive liver-specific enhancer of the human …