A census of human RNA-binding proteins
Nature Reviews Genetics, 2014•nature.com
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins
(RBPs) and ribonucleoproteins coordinate RNA processing and PTGR. The introduction of
large-scale quantitative methods, such as next-generation sequencing and modern protein
mass spectrometry, has renewed interest in the investigation of PTGR and the protein factors
involved at a systems-biology level. Here, we present a census of 1,542 manually curated …
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins
(RBPs) and ribonucleoproteins coordinate RNA processing and PTGR. The introduction of
large-scale quantitative methods, such as next-generation sequencing and modern protein
mass spectrometry, has renewed interest in the investigation of PTGR and the protein factors
involved at a systems-biology level. Here, we present a census of 1,542 manually curated …
Abstract
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation, transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins (RBPs) and ribonucleoproteins coordinate RNA processing and PTGR. The introduction of large-scale quantitative methods, such as next-generation sequencing and modern protein mass spectrometry, has renewed interest in the investigation of PTGR and the protein factors involved at a systems-biology level. Here, we present a census of 1,542 manually curated RBPs that we have analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression. Our analysis is a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.
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