[HTML][HTML] Myofibroblast transdifferentiation in obliterative bronchiolitis: TGF-β signaling through Smad3-dependent and-independent pathways
AM Ramirez, Z Shen, JD Ritzenthaler… - American journal of …, 2006 - Elsevier
We have shown that Smad3, an intracellular signal transducer for transforming growth factor-
β1 (TGF-β1), is required to elicit the full histological manifestations of obliterative airway
disease in a tracheal transplant model. This suggests that chronic allograft rejection results
in TGF-β1-induced Smad3 activation that leads to airway obliteration through
fibroproliferation and increased matrix deposition. In other systems, these latter events are
causally related to the transdifferentiation of fibroblasts into myofibroblasts, but their role in …
β1 (TGF-β1), is required to elicit the full histological manifestations of obliterative airway
disease in a tracheal transplant model. This suggests that chronic allograft rejection results
in TGF-β1-induced Smad3 activation that leads to airway obliteration through
fibroproliferation and increased matrix deposition. In other systems, these latter events are
causally related to the transdifferentiation of fibroblasts into myofibroblasts, but their role in …