Nogo limits neural plasticity and recovery from injury
ME Schwab, SM Strittmatter - Current opinion in neurobiology, 2014 - Elsevier
Current opinion in neurobiology, 2014•Elsevier
Highlights•Nogo-A limits neural repair and recovery after adult CNS injuries.•NgR1 and
S1PR2 are receptors for different domains of Nogo-A.•Nogo-A and NgR1 limit experience-
dependent neural plasticity.•Nogo-A and NgR1 stabilize synaptic, dendritic and axonal
anatomy in the adult CNS.The expression of Nogo-A and the receptor NgR1 limits the
recovery of adult mammals from central nervous system injury. Multiple studies have
demonstrated efficacy from targeting this pathway for functional recovery and neural repair …
S1PR2 are receptors for different domains of Nogo-A.•Nogo-A and NgR1 limit experience-
dependent neural plasticity.•Nogo-A and NgR1 stabilize synaptic, dendritic and axonal
anatomy in the adult CNS.The expression of Nogo-A and the receptor NgR1 limits the
recovery of adult mammals from central nervous system injury. Multiple studies have
demonstrated efficacy from targeting this pathway for functional recovery and neural repair …
Highlights
- Nogo-A limits neural repair and recovery after adult CNS injuries.
- NgR1 and S1PR2 are receptors for different domains of Nogo-A.
- Nogo-A and NgR1 limit experience-dependent neural plasticity.
- Nogo-A and NgR1 stabilize synaptic, dendritic and axonal anatomy in the adult CNS.
The expression of Nogo-A and the receptor NgR1 limits the recovery of adult mammals from central nervous system injury. Multiple studies have demonstrated efficacy from targeting this pathway for functional recovery and neural repair after spinal cord trauma, ischemic stroke, optic nerve injury and models of multiple sclerosis. Recent molecular studies have added S1PR2 as a receptor for the amino terminal domain of Nogo-A, and have demonstrated shared components for Nogo-A and CSPG signaling as well as novel Nogo antagonists. It has been recognized that neural repair involves plasticity, sprouting and regeneration. A physiologic role for Nogo-A and NgR1 has been documented in the restriction of experience-dependent plasticity with maturity, and the stability of synaptic, dendritic and axonal anatomy.
Elsevier