Axonal elongation into peripheral nervous system" bridges" after central nervous system injury in adult rats

S David, AJ Aguayo - Science, 1981 - science.org
Science, 1981science.org
The origin, termination, and length of axonal growth after focal central nervous system injury
was examined in adult rats by means of a new experimental model. When peripheral nerve
segments were used as" bridges" between the medulla and spinal cord, axons from neurons
at both these levels grew approximately 30 millimeters. The regenerative potential of these
central neurons seems to be expressed when the central nervous system glial environment
is changed to that of the peripheral nervous system.
The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments were used as "bridges" between the medulla and spinal cord, axons from neurons at both these levels grew approximately 30 millimeters. The regenerative potential of these central neurons seems to be expressed when the central nervous system glial environment is changed to that of the peripheral nervous system.
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