The immunosuppressive tumor environment is the major impediment to successful therapeutic vaccination in Neu transgenic mice

JE Burgents, TP Moran, ML West, NL Davis… - Journal of …, 2010 - journals.lww.com
We earlier showed that therapeutic vaccination of FVB/N mice with alphaviral replicon
particles expressing rat neuET-VRP induced regression of established neu-expressing
tumors. In this study, we evaluated the efficacy of neuET-VRPs in a tolerant mouse model
using mice with transgenic expression of neu. Using the same approach that induced
regression of 70 mm2 tumors in FVB/N mice, we were unable to inhibit tumor growth in
tolerant neu-N mice, despite showing neu-specific B-cell and T-cell responses post …