The fasting polypeptide FGF21 can enter brain from blood
H Hsuchou, W Pan, AJ Kastin - Peptides, 2007 - Elsevier
FGF21 recently has been proposed as a missing link in the biology of fasting, raising the
question of whether it directly reaches the brain. We used multiple time-regression analysis
to quantify the influx rate of this polypeptide across the blood–brain barrier (BBB), size-
exclusion chromatography to examine degradation, capillary depletion to differentiate entry
into brain parenchyma from retention in the microvasculature, and measurement of efflux
rate to determine a possible confounding effect on measurement of entry. FGF21 was 94 …
question of whether it directly reaches the brain. We used multiple time-regression analysis
to quantify the influx rate of this polypeptide across the blood–brain barrier (BBB), size-
exclusion chromatography to examine degradation, capillary depletion to differentiate entry
into brain parenchyma from retention in the microvasculature, and measurement of efflux
rate to determine a possible confounding effect on measurement of entry. FGF21 was 94 …