An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells
K Arai, EH Lo - Journal of Neuroscience, 2009 - Soc Neuroscience
K Arai, EH Lo
Journal of Neuroscience, 2009•Soc NeuroscienceWe show that cerebral endothelial cells secrete trophic factors that support the survival and
proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive
phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of
oxidative stress downregulate trophic factor production and disrupt the ability of cerebral
endothelial cells to support OPCs. These data suggest that a novel oligovascular niche may
be important for sustaining oligodendrocyte renewal and homeostasis in mammalian brain.
proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive
phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of
oxidative stress downregulate trophic factor production and disrupt the ability of cerebral
endothelial cells to support OPCs. These data suggest that a novel oligovascular niche may
be important for sustaining oligodendrocyte renewal and homeostasis in mammalian brain.
We show that cerebral endothelial cells secrete trophic factors that support the survival and proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of oxidative stress downregulate trophic factor production and disrupt the ability of cerebral endothelial cells to support OPCs. These data suggest that a novel oligovascular niche may be important for sustaining oligodendrocyte renewal and homeostasis in mammalian brain.
Soc Neuroscience