Epigenetic silencing of genes in human colon cancer
RA Liddle, RL Jirtle - Gastroenterology, 2006 - gastrojournal.org
Epigenetics means “in addition to the genetic information encoded in the DNA,” and refers to
the study of how environmental factors can change gene function and often organismal
phenotype without altering the DNA sequence. One of the first epigenetic modifications to be
identified was methylation of DNA, which in mammals, typically targets the nucleotide
cytosine when it is 5= of guanine. 1 Attachment of a methyl group to the 5 position of the
pyrimidine ring produces 5-methylcytosine. 2 Like cytosine, 5-methylcytosine has the ability …
the study of how environmental factors can change gene function and often organismal
phenotype without altering the DNA sequence. One of the first epigenetic modifications to be
identified was methylation of DNA, which in mammals, typically targets the nucleotide
cytosine when it is 5= of guanine. 1 Attachment of a methyl group to the 5 position of the
pyrimidine ring produces 5-methylcytosine. 2 Like cytosine, 5-methylcytosine has the ability …