RNA-binding residues in sequence space: conservation and interaction patterns
RV Spriggs, S Jones - Computational Biology and Chemistry, 2009 - Elsevier
RNA-binding proteins (RBPs) perform fundamental and diverse functions within the cell.
Approximately 15% of proteins sequences are annotated as RNA-binding, but with a
significant number of proteins without functional annotation, many RBPs are yet to be
identified. A percentage of uncharacterised proteins can be annotated by transferring
functional information from proteins sharing significant sequence homology. However,
genomes contain a significant number of orphan open reading frames (ORFs) that do not …
Approximately 15% of proteins sequences are annotated as RNA-binding, but with a
significant number of proteins without functional annotation, many RBPs are yet to be
identified. A percentage of uncharacterised proteins can be annotated by transferring
functional information from proteins sharing significant sequence homology. However,
genomes contain a significant number of orphan open reading frames (ORFs) that do not …