An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders
Y Yang, S Jiang, J Yan, Y Li, Z Xin, Y Lin… - Cytokine & growth factor …, 2015 - Elsevier
Recently, growing evidence has demonstrated that nuclear factor erythroid 2-related factor 2
(Nrf2) is a pivotal regulator of endogenous defense systems that function via the activation of
a set of protective genes, and this is particularly clear in the central nervous system (CNS).
Therefore, it is highly useful to summarize the current literature on the molecular
mechanisms and role of Nrf2 in the CNS. In this review, we first briefly introduce the
molecular features of Nrf2. We then discuss the regulation, cerebral actions, upstream …
(Nrf2) is a pivotal regulator of endogenous defense systems that function via the activation of
a set of protective genes, and this is particularly clear in the central nervous system (CNS).
Therefore, it is highly useful to summarize the current literature on the molecular
mechanisms and role of Nrf2 in the CNS. In this review, we first briefly introduce the
molecular features of Nrf2. We then discuss the regulation, cerebral actions, upstream …