Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents
T Akagi, Y Matsumura, M Yasui, E Minami… - Journal of …, 2014 - jstage.jst.go.jp
T Akagi, Y Matsumura, M Yasui, E Minami, H Inoue, T Masuda, H Tozaki-Saitoh, T Tamura…
Journal of pharmacological sciences, 2014•jstage.jst.go.jpWe investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in
which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure
produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal
microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was
significantly increased in the spinal cord of RCS-exposed mice and was localized in
microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS …
which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure
produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal
microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was
significantly increased in the spinal cord of RCS-exposed mice and was localized in
microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS …
Abstract
We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.
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