[HTML][HTML] SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
J Chen, Y Zhou, S Mueller-Steiner, LF Chen… - Journal of Biological …, 2005 - ASBMB
Accumulating evidence suggests that neurodegeneration induced by pathogenic proteins
depends on contributions from surrounding glia. Here we demonstrate that NF-κB signaling
in microglia is critically involved in neuronal death induced by amyloid-β (Aβ) peptides,
which are widely presumed to cause Alzheimer disease. Constitutive inhibition of NF-κB
signaling in microglia by expression of the nondegradable IκBα superrepressor blocked
neurotoxicity, indicating a pivotal role for microglial NF-κB signaling in mediating Aβ toxicity …
depends on contributions from surrounding glia. Here we demonstrate that NF-κB signaling
in microglia is critically involved in neuronal death induced by amyloid-β (Aβ) peptides,
which are widely presumed to cause Alzheimer disease. Constitutive inhibition of NF-κB
signaling in microglia by expression of the nondegradable IκBα superrepressor blocked
neurotoxicity, indicating a pivotal role for microglial NF-κB signaling in mediating Aβ toxicity …