Background and aims Macrophage differentiation is associated with the development of
atherosclerosis and plaque vulnerability and is regulated by transcription factor MafB. We
previously reported that MafB attenuates macrophage apoptosis, which is associated with
atherosclerotic plaque instability. The aim of this study was to elucidate the role of MafB in
the progression of atherosclerotic plaque. Methods We generated macrophage-specific
dominant-negative (DN) MafB transgenic mice and intercrossed DN-MafB mice with …