Noninvasive monitoring of radiotherapy-induced microvascular changes using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in a colorectal …

W Ceelen, P Smeets, W Backes, N Van Damme… - International Journal of …, 2006 - Elsevier
Purpose: To examine dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
with a macromolecular contrast agent (P792) to visualize effects of radiotherapy (RT) on
microvascular leakage in a colorectal cancer model. Methods and Materials: CC531 tumors
were induced in WAG/Rij rats. DCE-MRI was performed before and 5 days after 5× 5 Gy of
RT and parametric maps generated of the endothelial transfer constant (Ktrans) and the
fractional interstitial space (Ve) according to the Tofts model. Tissue pO2 mapping was …