ICAM-5—a novel two-facetted adhesion molecule in the mammalian brain
CG Gahmberg, L Tian, L Ning, H Nyman-Huttunen - Immunology letters, 2008 - Elsevier
Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-
5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of
adhesion proteins. These proteins bind to leukocyte β2-integrins (CD11/CD18), but ICAM-5
is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at
the time of birth, and is located in the soma and dendrites of neurons. It is structurally more
complex than the others, and also shows homophilic adhesion. Recent studies show that it …
5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of
adhesion proteins. These proteins bind to leukocyte β2-integrins (CD11/CD18), but ICAM-5
is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at
the time of birth, and is located in the soma and dendrites of neurons. It is structurally more
complex than the others, and also shows homophilic adhesion. Recent studies show that it …