[HTML][HTML] Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

Y Shirakata, T Komurasaki, H Toyoda… - Journal of Biological …, 2000 - ASBMB
Epiregulin is a new member of the epidermal growth factor (EGF) family purified from
conditioned medium of NIH-3T3 clone T7. Some EGF family growth factors play essential
roles in human keratinocytes in an autocrine manner. We show here that epiregulin is
another autocrine growth factor for human keratinocytes. Epiregulin stimulated human
keratinocyte proliferation under both subconfluent and confluent culture conditions in the
absence of exogenous EGF family growth factors. Immunoprecipitation of [35 S] methionine …