A key molecular pathway implicated in diverse neurodegenerative diseases is the
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence
strongly supports the hypothesis that accumulation of misfolded proteins leads to synaptic
dysfunction, neuronal apoptosis, brain damage, and disease. However, the mechanism by
which protein misfolding and aggregation trigger neurodegeneration and the identity of the
neurotoxic structure is still unclear. The aim of this article is to review the literature around …