[CITATION][C] Effect of Inhaled Leukotriene D4 on Human Airways

LJ Smith, R Patterson, R Kern, R Krell… - Annals of the New …, 1988 - Wiley Online Library
LJ Smith, R Patterson, R Kern, R Krell, P Bernstein
Annals of the New York Academy of Sciences, 1988Wiley Online Library
The sulfidopeptide leukotrienes (LT), LTC,, LTD,, and LTE,, formerly known as slow-reacting
substance of anaphylaxis (SRS-A),'have a variety of biological actions that mimic those
found during clinical asthma including bronchoconstriction~~ s increased vascular
perrneability, 6 cellular infiltration,'and increased mucus production. 8 Animal, in vitro, and
the initial human studies demonstrated that these leukotrienes are extremely potent
bronchoconstrictors, approximately 1000 times more potent than histamine. These studies …
The sulfidopeptide leukotrienes (LT), LTC,, LTD,, and LTE,, formerly known as slow-reacting substance of anaphylaxis (SRS-A),’have a variety of biological actions that mimic those found during clinical asthma including bronchoconstriction~~ s increased vascular perrneability, 6 cellular infiltration,’and increased mucus production. 8 Animal, in vitro, and the initial human studies demonstrated that these leukotrienes are extremely potent bronchoconstrictors, approximately 1000 times more potent than histamine. These studies also raised several questions regarding the potency of the leukotrienes in normal and asthmatic subjects, their ability to produce airway hyperreactivity, and their mechanism of action. Therefore, we performed a series of studies using aerosolized LTD, that were designed to answer these questions and further characterize the human airway response to the sulfidopeptide leukotrienes.
Wiley Online Library