Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

R Bernardi, PP Pandolfi - Nature reviews Molecular cell biology, 2007 - nature.com
Nature reviews Molecular cell biology, 2007nature.com
The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear
body (PML-NB) and is crucially required for the proper assembly of this macromolecular
nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and
Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated
in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour
the sequestration and release of proteins, mediate their post-translational modifications and …
Abstract
The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.
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