[HTML][HTML] Runx1 regulation of Pu. 1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy
X Gu, Z Hu, Q Ebrahem, JS Crabb, RZ Mahfouz… - Journal of Biological …, 2014 - ASBMB
Gene activation requires cooperative assembly of multiprotein transcription factor-
coregulator complexes. Disruption to cooperative assemblage could underlie repression of
tumor suppressor genes in leukemia cells. Mechanisms of cooperation and its disruption
were therefore examined for PU. 1 and RUNX1, transcription factors that cooperate to
activate hematopoietic differentiation genes. PU. 1 is highly expressed in leukemia cells,
whereas RUNX1 is frequently inactivated by mutation or translocation. Thus, coregulator …
coregulator complexes. Disruption to cooperative assemblage could underlie repression of
tumor suppressor genes in leukemia cells. Mechanisms of cooperation and its disruption
were therefore examined for PU. 1 and RUNX1, transcription factors that cooperate to
activate hematopoietic differentiation genes. PU. 1 is highly expressed in leukemia cells,
whereas RUNX1 is frequently inactivated by mutation or translocation. Thus, coregulator …