Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies
HM Bramlett, WD Dietrich - Progress in brain research, 2007 - Elsevier
The pathophysiology of brain and spinal cord injury (SCI) is complex and involves multiple
injury mechanisms that are spatially and temporally specific. It is now appreciated that many
of these injury mechanisms remain active days to weeks after a primary insult. Long-term
survival studies in clinically relevant experimental studies have documented the structural
changes that continue at the level of the insult as well as in remote brain structures. After
traumatic brain injury (TBI), progressive atrophy of both gray and white matter structures …
injury mechanisms that are spatially and temporally specific. It is now appreciated that many
of these injury mechanisms remain active days to weeks after a primary insult. Long-term
survival studies in clinically relevant experimental studies have documented the structural
changes that continue at the level of the insult as well as in remote brain structures. After
traumatic brain injury (TBI), progressive atrophy of both gray and white matter structures …