Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade
CP Pallasch, S Ulbrich, R Brinker, M Hallek, RA Uger… - Leukemia research, 2009 - Elsevier
CD200 plays a key role in regulating the immune system and has been shown to be
upregulated on the surface of different tumors including chronic lymphocytic leukemia. In this
study we addressed the effects of CD200 over-expression in CLL cells on autologous T cells
in a mixed lymphocyte reaction system. We used native and CD40 ligand (CD40L)-
stimulated CLL cells as antigen-presenting cells (APCs) to expand autologous T cells of 14
patients. T cell proliferation over 3 weeks of in vitro culture was significantly enhanced …
upregulated on the surface of different tumors including chronic lymphocytic leukemia. In this
study we addressed the effects of CD200 over-expression in CLL cells on autologous T cells
in a mixed lymphocyte reaction system. We used native and CD40 ligand (CD40L)-
stimulated CLL cells as antigen-presenting cells (APCs) to expand autologous T cells of 14
patients. T cell proliferation over 3 weeks of in vitro culture was significantly enhanced …