[HTML][HTML] Synergistic B cell activation by CD40 and the B cell antigen receptor: role of B lymphocyte antigen receptor-mediated kinase activation and tumor necrosis …
SA Haxhinasto, GA Bishop - Journal of Biological Chemistry, 2004 - ASBMB
Optimal activation of B-lymphocytes depends both upon expression of various cell surface
receptors and adequate integration of signaling pathways. This requires signals generated
upon recognition of antigen by the B lymphocyte antigen receptor (BCR) as well as
additional signals provided by cognate interaction with T helper cells, including the CD40-
CD154 interaction. Engagement of both the BCR and CD40 results in synergistic activation
of B cells. Previous studies identified tumor necrosis factor receptor-associated factor (TRAF) …
receptors and adequate integration of signaling pathways. This requires signals generated
upon recognition of antigen by the B lymphocyte antigen receptor (BCR) as well as
additional signals provided by cognate interaction with T helper cells, including the CD40-
CD154 interaction. Engagement of both the BCR and CD40 results in synergistic activation
of B cells. Previous studies identified tumor necrosis factor receptor-associated factor (TRAF) …