PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline
SJ Barton, GH Koppelman, JM Vonk… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Several studies have suggested that chromosome 19q13. 1-3 contains
asthma susceptibility genes. OBJECTIVE: Linkage and association analyses using 587
United Kingdom and Dutch asthma families (n= 2819 subjects) were used to investigate this
region. METHODS: A 3-phase procedure was used:(1) linkage and association analyses
using 15 microsatellite markers spanning 14.4 mega base pairs (Mbps) on 19q13,(2) fine
mapping of the refined region using 26 haplotype tagging single nucleotide polymorphisms …
asthma susceptibility genes. OBJECTIVE: Linkage and association analyses using 587
United Kingdom and Dutch asthma families (n= 2819 subjects) were used to investigate this
region. METHODS: A 3-phase procedure was used:(1) linkage and association analyses
using 15 microsatellite markers spanning 14.4 mega base pairs (Mbps) on 19q13,(2) fine
mapping of the refined region using 26 haplotype tagging single nucleotide polymorphisms …