Polyinosinic: polycytidylic acid induces protein kinase D–dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells
F Rezaee, N Meednu, JA Emo, B Saatian… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Disruption of the epithelial barrier might be a risk factor for allergen
sensitization and asthma. Viral respiratory tract infections are strongly associated with
asthma exacerbation, but the effects of respiratory viruses on airway epithelial barrier
function are not well understood. Many viruses generate double-stranded RNA, which can
lead to airway inflammation and initiate an antiviral immune response. OBJECTIVES: We
investigated the effects of the synthetic double-stranded RNA polyinosinic: polycytidylic acid …
sensitization and asthma. Viral respiratory tract infections are strongly associated with
asthma exacerbation, but the effects of respiratory viruses on airway epithelial barrier
function are not well understood. Many viruses generate double-stranded RNA, which can
lead to airway inflammation and initiate an antiviral immune response. OBJECTIVES: We
investigated the effects of the synthetic double-stranded RNA polyinosinic: polycytidylic acid …