[HTML][HTML] Chimeric mouse model of hepatitis B virus infection
M Dandri, J Petersen - Journal of hepatology, 2012 - Elsevier
Chronic infection with hepatitis B virus (HBV) continues to be a major health problem
affecting about 400 million people worldwide. The narrow species tropism of HBV has
hindered progresses in HBV research and development of more efficient treatments. Due to
strong restraints encountered using chimpanzees and animal models based on HBV-related
viruses, recent developments focused on using the natural target of HBV infection: the
human hepatocyte. However, in vitro susceptibility of human hepatocytes to HBV is limited …
affecting about 400 million people worldwide. The narrow species tropism of HBV has
hindered progresses in HBV research and development of more efficient treatments. Due to
strong restraints encountered using chimpanzees and animal models based on HBV-related
viruses, recent developments focused on using the natural target of HBV infection: the
human hepatocyte. However, in vitro susceptibility of human hepatocytes to HBV is limited …