Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient
HBV-DNA integration frequently occurs in HBV-related hepatocellular carcinoma (HCC), but
whether HBV antigens are expressed in HCC cells and can be targeted by immune
therapeutic strategies remains controversial. Here, we first characterized HBV antigen
expression in HCC metastases, occurring in a patient who had undergone liver
transplantation for HBV-related HCC. We then deployed for the first time in HCC autologous
T cells, genetically modified to express an HBsAg specific T cell receptor, as therapy against …
whether HBV antigens are expressed in HCC cells and can be targeted by immune
therapeutic strategies remains controversial. Here, we first characterized HBV antigen
expression in HCC metastases, occurring in a patient who had undergone liver
transplantation for HBV-related HCC. We then deployed for the first time in HCC autologous
T cells, genetically modified to express an HBsAg specific T cell receptor, as therapy against …