[HTML][HTML] High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR
RL Shields, AK Namenuk, K Hong, YG Meng… - Journal of Biological …, 2001 - ASBMB
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated
immune responses with cellular effector functions. A high resolution map of the binding site
on human IgG1 for human FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, and FcRn receptors has been
determined. A common set of IgG1 residues is involved in binding to all FcγR; FcγRII and
FcγRIII also utilize residues outside this common set. In addition to residues which, when
altered, abrogated binding to one or more of the receptors, several residues were found that …
immune responses with cellular effector functions. A high resolution map of the binding site
on human IgG1 for human FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, and FcRn receptors has been
determined. A common set of IgG1 residues is involved in binding to all FcγR; FcγRII and
FcγRIII also utilize residues outside this common set. In addition to residues which, when
altered, abrogated binding to one or more of the receptors, several residues were found that …