[HTML][HTML] Aging augments IL-17 T-cell alloimmune responses
BM Tesar, W Du, AC Shirali, WE Walker… - American Journal of …, 2009 - Elsevier
As increasing numbers of elderly patients require solid organ transplantation, the need to
better understand how aging modifies alloimmune responses increases. Here, we examined
whether aged mice exhibit augmented, donor-specific memory responses prior to
transplantation. We found that elevated donor-specific IL-17, but not IFN-γ, responses were
observed in aged mice compared to young mice prior to transplantation. Further
characterization of the heightened IL-17 alloim-mune response with aging demonstrated …
better understand how aging modifies alloimmune responses increases. Here, we examined
whether aged mice exhibit augmented, donor-specific memory responses prior to
transplantation. We found that elevated donor-specific IL-17, but not IFN-γ, responses were
observed in aged mice compared to young mice prior to transplantation. Further
characterization of the heightened IL-17 alloim-mune response with aging demonstrated …