Absence of MyD88 signaling induces donor-specific kidney allograft tolerance
H Wu, GA Noordmans, MR O'Brien, J Ma… - Journal of the …, 2012 - journals.lww.com
Toll-like receptors (TLRs) play a fundamental role in innate immunity and provide a link
between innate and adaptive responses to an allograft; however, whether the development
of acute and chronic allograft rejection requires TLR signaling is unknown. Here, we studied
TLR signaling in a fully MHC-mismatched, life-sustaining murine model of kidney allograft
rejection. Mice deficient in the TLR adaptor protein MyD88 developed donor antigen-specific
tolerance, which protected them from both acute and chronic allograft rejection and …
between innate and adaptive responses to an allograft; however, whether the development
of acute and chronic allograft rejection requires TLR signaling is unknown. Here, we studied
TLR signaling in a fully MHC-mismatched, life-sustaining murine model of kidney allograft
rejection. Mice deficient in the TLR adaptor protein MyD88 developed donor antigen-specific
tolerance, which protected them from both acute and chronic allograft rejection and …