[HTML][HTML] Clinical-scale isolation of 'minimally manipulated'cytomegalovirus-specific donor lymphocytes for the treatment of refractory cytomegalovirus disease
M Odendahl, GU Grigoleit, H Bönig, M Neuenhahn… - Cytotherapy, 2014 - Elsevier
Background aims Reactivation of cytomegalovirus (CMV) after hematopoietic stem cell
transplantation remains a major cause of morbidity despite improved antiviral drug
therapies. Selective restoration of CMV immunity by adoptive transfer of CMV-specific T cells
is the only alternative approach that has been shown to be effective and non-toxic. We
describe the results of clinical-scale isolations of CMV-specific donor lymphocytes with the
use of a major histocompatibility (MHC) class I peptide streptamer-based isolation method …
transplantation remains a major cause of morbidity despite improved antiviral drug
therapies. Selective restoration of CMV immunity by adoptive transfer of CMV-specific T cells
is the only alternative approach that has been shown to be effective and non-toxic. We
describe the results of clinical-scale isolations of CMV-specific donor lymphocytes with the
use of a major histocompatibility (MHC) class I peptide streptamer-based isolation method …