Analysis of the alloreactive T cell repertoire in man: I. Differences in precursor frequency for cytotoxic T cell responses against allogeneic MHC molecules in unrelated …
CEM SHARROCK, S MAN… - …, 1987 - journals.lww.com
CEM SHARROCK, S MAN, W WANACHIWANAWIN, JR Batchelor
Transplantation, 1987•journals.lww.comWe demonstrate here that in man the frequency of cytotoxic T cells specific for a given set of
allo-major histocompatibility complex (MHC) antigens varies among unrelated individuals.
This has been established by limiting dilution analysis of human peripheral blood
lymphocytes (HPBL) in the presence of irradiated autologous filler cells, T cell growth
factors, and irradiated HPBL carrying allo-MHC antigens.
allo-major histocompatibility complex (MHC) antigens varies among unrelated individuals.
This has been established by limiting dilution analysis of human peripheral blood
lymphocytes (HPBL) in the presence of irradiated autologous filler cells, T cell growth
factors, and irradiated HPBL carrying allo-MHC antigens.
Abstract
We demonstrate here that in man the frequency of cytotoxic T cells specific for a given set of allo-major histocompatibility complex (MHC) antigens varies among unrelated individuals. This has been established by limiting dilution analysis of human peripheral blood lymphocytes (HPBL) in the presence of irradiated autologous filler cells, T cell growth factors, and irradiated HPBL carrying allo-MHC antigens.
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