The role of in vitro alloreactive T-cell functional tests in the selection of HLA matched and mismatched haematopoietic stem cell donors
M Jeras - Transplant Immunology, 2002 - Elsevier
Acute graft vs. host (GVH) disease and graft rejection are most frequently caused by
undetected or disregarded genetically based disparities between the donor and recipient of
bone marrow derived haematopoietic stem cells (HSC). Incompatibilities in extremely
polymorphic human leukocyte antigens (HLA), and in certain cases also minor
histocompatibility antigens, represent the most important driving force of such unwanted
events, threatening the successful outcome of haematopoietic stem cell transplantation …
undetected or disregarded genetically based disparities between the donor and recipient of
bone marrow derived haematopoietic stem cells (HSC). Incompatibilities in extremely
polymorphic human leukocyte antigens (HLA), and in certain cases also minor
histocompatibility antigens, represent the most important driving force of such unwanted
events, threatening the successful outcome of haematopoietic stem cell transplantation …