A very high level of crossreactivity is an essential feature of the T-cell receptor

D Mason - Immunology today, 1998 - cell.com
D Mason
Immunology today, 1998cell.com
It is commonly accepted that a high level of antigen specificity is a feature of T-cell activation.
However, here, Don Mason argues that a comprehensive response to foreign antigens
requires that T cells are widely crossreactive, such that one cell reacts productively with
approximately 10 6 different MHC-associated minimal peptide epitopes.
Abstract
It is commonly accepted that a high level of antigen specificity is a feature of T-cell activation. However, here, Don Mason argues that a comprehensive response to foreign antigens requires that T cells are widely crossreactive, such that one cell reacts productively with approximately 106 different MHC-associated minimal peptide epitopes.
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