[HTML][HTML] Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: implications for graft engineering
P Scheinberg, DA Price, DR Ambrozak, AJ Barrett… - Experimental …, 2006 - Elsevier
OBJECTIVE: The selective elimination of alloreactive T cells from donor stem cell grafts prior
to hematopoietic stem cell transplantation (HSCT) is an important goal in the prevention of
graft-vs-host disease (GVHD). However, in HLA-identical donor-recipient pairs, it has proven
difficult to identify alloreactive T cells using in vitro systems pretransplant due, in part, to their
low frequency and a lack of methodological standardization. To better understand the
alloresponse between HLA-identical related pairs, we characterized the alloreactive T cells …
to hematopoietic stem cell transplantation (HSCT) is an important goal in the prevention of
graft-vs-host disease (GVHD). However, in HLA-identical donor-recipient pairs, it has proven
difficult to identify alloreactive T cells using in vitro systems pretransplant due, in part, to their
low frequency and a lack of methodological standardization. To better understand the
alloresponse between HLA-identical related pairs, we characterized the alloreactive T cells …