[HTML][HTML] Hyperlipidemia alters regulatory T cell function and promotes resistance to tolerance induction through costimulatory molecule blockade
J Bagley, J Yuan, A Chandrakar, J Iacomini - American Journal of …, 2015 - Elsevier
Recent work from our laboratory has shown that hyperlipidemia promotes accelerated
rejection of vascularized cardiac allografts in mice by inducing anti-donor Th17 reactivity
and production of IL-17. Here, we show that hyperlipidemia also affects FoxP3+ regulatory T
cells (Tregs). Hyperlipidemia promotes the development of Tregs that express low levels of
CD25. Hyperlipidemia also promotes a decrease in central Tregs and an increase in effector
Tregs that appears to account for the increase in the frequency of CD25 low Tregs …
rejection of vascularized cardiac allografts in mice by inducing anti-donor Th17 reactivity
and production of IL-17. Here, we show that hyperlipidemia also affects FoxP3+ regulatory T
cells (Tregs). Hyperlipidemia promotes the development of Tregs that express low levels of
CD25. Hyperlipidemia also promotes a decrease in central Tregs and an increase in effector
Tregs that appears to account for the increase in the frequency of CD25 low Tregs …