[HTML][HTML] Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity
MA Brehm, KA Daniels, B Priyadharshini… - American Journal of …, 2010 - Elsevier
Viral infections have been associated with the rejection of transplanted allografts in humans
and mice, and the induction of tolerance to allogeneic tissues in mice is abrogated by an
ongoing viral infection and inhibited in virus-immune mice. One proposed mechanism for
this 'heterologous immunity'is the induction of alloreactive T cell responses that cross-react
with virus-derived antigens. These cross-reactive CD8 T cells are generated during acute
viral infection and survive into memory, but their ability to partake in the immune response to …
and mice, and the induction of tolerance to allogeneic tissues in mice is abrogated by an
ongoing viral infection and inhibited in virus-immune mice. One proposed mechanism for
this 'heterologous immunity'is the induction of alloreactive T cell responses that cross-react
with virus-derived antigens. These cross-reactive CD8 T cells are generated during acute
viral infection and survive into memory, but their ability to partake in the immune response to …