Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries
AB Collins, EE Schneeberger, MA Pascual… - Journal of the …, 1999 - journals.lww.com
The distinction between acute humoral rejection (AHR) and acute cellular rejection (ACR) in
renal allografts is therapeutically important, but pathologically difficult. Since AHR is
probably mediated by antibodies to the donor endothelium that activate the classical
complement pathway, it was hypothesized that peritubular capillary C4d deposition might
distinguish this group. Renal biopsies (n= 16) from 10 patients with AHR who had acute graft
dysfunction, neutrophils in peritubular capillaries, and a concurrent positive crossmatch …
renal allografts is therapeutically important, but pathologically difficult. Since AHR is
probably mediated by antibodies to the donor endothelium that activate the classical
complement pathway, it was hypothesized that peritubular capillary C4d deposition might
distinguish this group. Renal biopsies (n= 16) from 10 patients with AHR who had acute graft
dysfunction, neutrophils in peritubular capillaries, and a concurrent positive crossmatch …