[HTML][HTML] Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model
Depletional strategies directed toward achieving tolerance induction in organ
transplantation have been associated with an increased incidence and risk of antibody-
mediated rejection (AMR) and graft injury. Our clinical data suggest correlation of increased
serum B cell activating factor/survival factor (BAFF) with increased risk of antibody-mediated
rejection in alemtuzumab treated patients. In the present study, we tested the ability of BAFF
blockade (TACI-Ig) in a nonhuman primate AMR model to prevent alloantibody production …
transplantation have been associated with an increased incidence and risk of antibody-
mediated rejection (AMR) and graft injury. Our clinical data suggest correlation of increased
serum B cell activating factor/survival factor (BAFF) with increased risk of antibody-mediated
rejection in alemtuzumab treated patients. In the present study, we tested the ability of BAFF
blockade (TACI-Ig) in a nonhuman primate AMR model to prevent alloantibody production …