Relationship between mean fluorescence intensity and C1q/C3d-fixing capacities of anti-HLA antibodies
G Claisse, L Absi, F Cognasse, E Alamartine… - Human immunology, 2017 - Elsevier
Background Complement-binding assays are proposed to better stratify the risk of antibody-
mediated rejection associated-graft failure. Despite promising clinical results, some have
suggested that the MFI of anti-HLA antibodies may influence these tests. Methods We
investigated the impact of Abs MFI reduction, induced by plasmapheresis, on C1q-and C3d-
binding assays. Sera provided from 7 sensitized kidney transplant patients were analyzed.
Results Four hundreds and thirty-three SABs were analyzed. Before plasmapheresis, when …
mediated rejection associated-graft failure. Despite promising clinical results, some have
suggested that the MFI of anti-HLA antibodies may influence these tests. Methods We
investigated the impact of Abs MFI reduction, induced by plasmapheresis, on C1q-and C3d-
binding assays. Sera provided from 7 sensitized kidney transplant patients were analyzed.
Results Four hundreds and thirty-three SABs were analyzed. Before plasmapheresis, when …